FIG. 1 Is A Plot Of

Swiss Patent No. CH-612.271 discloses a non-invasive technique to find out biological substances in samples or by means of the pores and skin utilizing an attenuated whole reflection (ATR) prism directly positioned towards a sample to be analyzed (for instance the lips or BloodVitals SPO2 the tongue). See also Hormone & Metabolic Res/suppl. ATR prism is attenuated in keeping with the glucose focus in the optically thinner medium. This attenuation is ascertained and processed into glucose dedication information. U.S. Pat. No. 3,958,560 discloses a non-invasive device for determining glucose in a affected person's eye. IR radiations when passing through the attention. GB Patent Application No. 2,033,575 discloses a detector system for investigating substances in a affected person's blood stream, specifically CO 2 , oxygen or glucose. Optical radiations embody UV in addition to IR radiations. U.S. Pat. No. 3.638,640 discloses a way and an apparatus for measuring oxygen and other substances in blood and dwelling tissues. 660, 715 and 805 nm.



GB Patent Application No. 2,075,668 describes a spectrophotometric apparatus for measuring and monitoring in-vivo and non-invasively the metabolism of physique organs, e.g., modifications in the oxido-discount state hemoglobin and cellular cytochrome as well as blood move charges in numerous organs such as the brain, coronary heart, kidney and the like. 700-1300 nm vary which have been shown to effectively penetrate the physique tissues all the way down to distances of several mm. Another detector placed coaxially with the supply picks up a again radiated reference signal. Both the analytical and reference alerts from the detectors are fed to a computing circuit, the output of which offers useful readout information regarding the wanted analytical information. 15 nm where typical glucose absorption bands exists. FIG. 4 of the above reference patent U.S. Pat. No. 4,655,225 exhibits the change in optical density plotted as a perform of glucose focus between zero and BloodVitals 1.0 mol/1 for 2 selective wavelengths of 2100 and 1100 nm.



That figure indicates correctly that the optical absorption of glucose measured at near infrared wavelengths of 2098 nm will increase proportionally with glucose focus. It moreover signifies that the optical absorption of glucose measured at a close to infrared wavelength of 1100 nm decreases slightly with glucose focus. 4,655,225 as a non-invasive glucose analyzer for BloodVitals measuring the focus of glucose present in people. Furthermore, along with the near infrared absorption of glucose as shown in FIG. Four of that embodiment, the light intensity either transmitted by means of or BloodVitals SPO2 mirrored from tissue at this characteristic wavelength will likely be even smaller than proven due to the presence of different absorbing elements in the blood and interstitial fluid reminiscent of proteins and other tissue constituents which absorb radiation at this chosen wavelength. This invention is described as utilized to the special case of glucose measurement in vivo using near infrared radiation.